PUBLICACIONES (ÚLTIMOS AÑOS)

Bertona D, Pujato N, Bontempi I, Gonzalez V, Cabrera G, Gugliotta L, Hozbor D, Nicastro A, Calvinho L, Marcipar IS. Development and assessment of a new cage-like particle adjuvant. J Pharm Pharmacol. 2017 Jun 30. doi: 10.1111/jphp.12768.

Bergero PE1, Fabricius G, Hozbor DF, Theeten H, Hens N. Potential Impact of Changes in the Schedule for Primary DTP Immunization as Control Strategy for Pertussis. Pediatr Infect Dis J. 2017 .doi: 10.1097/INF.0000000000001752. ISSN: 0891-3668

María Emilia Gaillard, Daniela Bottero, María Eugenia Zurita, Francisco Carriquiriborde, Pablo Martin Aispuro, Erika Bartel, David Sabater-Martínez, María Sol Bravo, Celina Castuma, Daniela Flavia Hozbor. Pertussis Maternal Immunization: Narrowing the Knowledge Gaps on the Duration of Transferred Protective Immunity and on Vaccination Frequency. Front. Immunol. 2017 | https://doi.org/10.3389/fimmu.2017.01099. ISSN 1664-3224

Bottero, D.; Zurita, ME.; Gaillard, ME.; Bartel, E.; Vercellini C.; and Hozbor, D. Membrane vesicles derived from bordetella bronchiseptica: active constituent of a new vaccine against infections caused by this pathogen. Applied and Environmental Microbiology Noviembre 2017. AEM.01877-17. doi: 10.1128/AEM.01877-17 ISSN: 1098-5336.

G. Fabricius, P. Martin Aispuro, P. Bergero, D. Bottero, M. Gabrielli and D. Hozbor. Pertussis epidemiology in argentina: trends after the introduction of maternal immunization. Epidemiology and Infection. Marzo 2018 en prensa.

Bottero D, Gaillard M, Fingermann M, Weltman G, Fernández J, Sisti F, Graieb A, Roberts R, Rico O, Ríos G, Regueira M, Binsztein N and Hozbor D. Pulse field gel electrophoresis, pertactin, pertussis toxin S1 subunit polymorphisms and surfaceome analysis of vaccine and clinical Bordetella pertussis strains. Clinical and Vaccine Immunology 2007. 14:1490-1498. ISSN 1556-6811

Guiso N and Hozbor D. Bordetella pertussis polymorphism and pertussis vaccines. Clin Vaccine Immunol. 2008 15:394; author reply 394-5. ISSN 1556-6811

Roberts R, Moreno G, Bottero D, Gaillard ME, Fingermann M, Graieb A, Rumbo M, Hozbor D. Outer membrane vesicles as acellular vaccine against pertussis. Vaccine. 2008 26(36):4639-46.ISSN 0264-410X Elsevier

Hozbor D, Mooi F, Flores D, Weltman G, Bottero D, Fossati S, Lara C, Gaillard ME, Pianciola L, Zurita E, Fioriti A, Archuby D, Galas M, Binsztein N, Regueira M, Castuma C, Fingermann M, Graieb A. J Infect. Pertussis Epidemiology in Argentina Trends Over 2004-2007. 2009 59(4):225-31. ISSN: 0163-4453

Von Specht M, Grenon S, Tagliaferri P, López O, Regueira M, Fosatti S, Weltman G, Hozbor D. Whooping cough: clinical and epidemiological characteristics of 20 confirmed cases of the Paediatric Hospital of Misiones province. Arch Argent Pediatr. 2009 ;107:449-52. ISSN 0325-0075versión impresa. ISSN 1668-3501versión on-line

Errea A, Moreno G, Sisti F, Fernández J, Rumbo M, Hozbor DF. Mucosal innate response stimulation induced by lipopolysaccharide protects against Bordetella pertussis colonization. Med Microbiol Immunol. 2010 199(2):103-8. ISSN: 0300-8584 (print version) ISSN: 1432-1831 (electronic version)

Pianciola L, Mazzeo M, Flores D, Hozbor D. Optimization of processing and storage of clinical samples to be used for the molecular diagnosis of pertussis. Rev Argent Microbiol. 2010 ;42(2):108-13. ISSN 0325-7541, OCLC: 85449370

Ulloa-Gutierrez R, Hozbor D, Avila-Aguero ML, Caro J, König CH, Tan T, Plotkin S. Hum Vaccin. The global pertussis initiative: Meeting report from the regional Latin America meeting, Costa Rica, 5-6 December, 2008. 1;6(11). Print ISSN: 1554-8600 Online ISSN: 1554-8619 (2010)

Lopardo, H, Ruvinsky S, Casimir L, Bologna, R, Mecikovsky D, and Hozbor, D. Fatal laryngotracheitis caused by Bordetella bronchiseptica in a girl with AIDS. Journal of Pediatric Infectious Diseases. 2011 Volume 6 (2) IOS Press – Jan 1, 2 ISSN: 1305-7707 print. ISSN: 1305-7693 online

Asensio C., Moreno G, Gaillard ME, Bottero D., Zurita E., Rumbo M., van der Ley P., van der Ark, A., and Hozbor D. Outer membrane vesicles obtained from Bordetella pertussis Tohama expressing the lipid A deacylase PagL as a novel acellular vaccine candidate. Vaccine 2011 29:1649-56. ISSN 0264-410X Elsevier

Gaillard ME, Bottero D, Castuma CE, Basile LA, Hozbor D. Laboratory adaptation of Bordetella pertussis is associated with the loss of Type Three Secretion System functionality. Infect Immun. 2011 Jul 5. [Epub ahead of print] Print ISSN: 0019-9567

Sisti F., Fernández J., Higgins, S., Cassabuono A., Couto A., Mills K and Hozbor D. A deep rough type structure in Bordetella bronchiseptica lipopolysaccharide modulates host immune responses. Microbiology and Immunology. 2011. 55:847-54. doi: 10.1111/j.1348-0421.2011.00395.x. ISSN: 1348-0421

Bottero, Daniela; Gaillard, María; Basile, Laura; Fritz, Mariana; Hozbor, Daniela. Genotypic and phenotypic characterization of Bordetella pertussis strains used in different vaccine formulations in Latin America. J Appl Microbiol. 2012 Jun;112(6):1266-76. doi: 10.1111/j.1365-2672.2012.05299.x. Epub 2012 Apr 25. ISSN: 1365-2672

G. Fabricius, P. Bergero, M. Ormazabal, A. Maltz And D. Hozbor. Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina. Received 8 April 2012; Final revision 18 May 2012; Accepted 31 May 2012. Journal of Epidemiology and Infection ISSN: 0950-2688 EISSN: 1469-4409. 2013 Apr;141(4):718-34. doi: 10.1017/S0950268812001380.

Bottero, Daniela; Griffith, Matthew M.; Lara, Claudia; Flores, Darío; Pianciola, Luis; Gaillard María Emilia, Mazzeo, Melina; Zamboni, Maria Ines; Spoleti, María Julia; Anchart, Eduardo; Ruggeri, Diego; Sorhouet, Cecilia; Fiori, Silvana; Galas, Marcelo; Tondella, Maria L. and Hozbor, Daniela. Bordetella holmesii in children suspected of pertussis in Argentina. Aceptado para su publicación en Epidemiology and Infection. Mayo de 2012. Epidemiology and Infection / Volume 141 / Issue 04 / April 2013, pp 714-717. ISSN: 0950-2688 EISSN: 1469-4409

Van der Ark AA, Hozbor DF, Boog CJ, Metz B, van den Dobbelsteen GP, van Els CA. Resurgence of pertussis calls for re-evaluation of pertussis animal models. Expert Rev Vaccines. 2012 (9):1121-37. doi: 10.1586/erv.12.83. ISSN: 1476-0584, 1744-8395

Sisti F, Ha DG, O’Toole GA, Hozbor DF, Fernandez J. Cyclic-Di-Gmp Signaling Regulates Motility And Biofilm Formation In Bordetella bronchiseptica. Microbiology. 2013 Mar 8. Print ISSN: 1350-0872; Online ISSN: 1465-2080.

Eugenia Zurita, Griselda Moreno, Agustina Errea, Maximiliano Ormazabal, Martin Rumbo, and Daniela Hozbor. Stimulated innate resistance event (StIR) in Bordetella pertussis infection is dependent on reactive oxygen species production. Infect Immun. 2013 Jul;81(7):2371-8. doi: 10.1128/IAI.00336-13. Print ISSN: 0019-9567; Online ISSN: 1098-5522

Pesco P, Bergero P, Fabricius G y Hozbor D. Assessment of pertussis vaccination strategies using a mathematical model of disease transmission. Arch Argent Pediatr. 2013 Oct;111(5):377-83. doi: 10.1590/S0325-00752013000500004. ISSN 0325-0075 versión impresa ISSN 1668-3501

Griselda Moreno, Agustina Errea, Laurye Van Maele, Roy Roberts, Hélène Léger, Jean Claude Sirard, Arndt Benecke, Martin Rumbo, Daniela Hozbor. Toll- like receptor 4 orchestrates neutrophil recruitment into airways during the first hours of Bordetella pertussis infection. Microbes Infect. 2013 Sep-Oct;15(10-11):708-18. doi: 10.1016/j.micinf.2013.06.010. ISSN: 1286-4579)

Bottero D., Gaillard ME, Errea A., Moreno G., Zurita E., Pianciola L., Rumbo M. and Hozbor D. Bordetella parapertussis as an acellular vaccine against Bordetella parapertussis and Bordetella pertussis infection. Vaccine. 2013 Oct 25;31(45):5262-8. doi: 10.1016/j.vaccine.2013.08.059. ISSN: 0264-410X

Gaillard ME, Bottero D, Errea A, Ormazabal M, Zurita ME, Moreno G, Rumbo M, Castuma C, Bartel E, Flores D, van der Ley P, van der Ark A, and Hozbor D. Acellular pertussis vaccine based on outer membrane vesicles capable of conferring both long-lasting immunity and protection against different strain genotypes. Vaccine 2014, 32(8):931-937. ISSN: 0264-410X

Marieke J Bart , Simon R. Harris , Reza Advani , Yoshichika Arakawa , Daniela Bottero , Valérie Bouchez , Pamela Cassiday , Chuen-Sheue Chiang , Tine Dalby , Norman K Fry , María Emilia Gaillard , Marjolein van Gent , Nicole Guiso , Hans Hallander , Eric T Harvill , Qiushui He , Han GJ van der Heide , Kees Heuvelman , Daniela Hozbor , Kazunari Kamachi , Gennady I Karataev , Ruiting Lan , Anna Lutyńska , Ram P Maharjan , Prof. Jussi Mertsola , Tatsuo Miyamura , Sophie Octavia , Andrew Preston , Michael A. Quail , Vitali Sintchenko , Paola Stefanelli , Maria Lucia Tondella , Raymond S W Tsang , Yinghua Xu , Shu-Man Yao , Shumin Zhang , Frits R Mooi. Global population structure and evolution of Bordetella pertussis and their relationship with vaccination. MBio. 2014 Apr 22;5(2):e01074. doi: 10.1128/mBio.01074-14. Online ISSN: 2150-7511

Pablo Pesco; Paula Bergero; Gabriel Fabricius; Daniela Hozbor. Modelling the effect of changes in vaccine effectiveness and transmission contact rates on pertussis epidemiology. Epidemics. 2014 Jun;7:13-21. doi: 10.1016/j.epidem.2014.04.001. ISSN: 1755-4365

Noelia Olivera, Celina E. Castuma, Daniela Hozbor, María E. Gaillard, Martín Rumbo, and Ricardo M. Gómez. Immunization with the Recombinant Cholera Toxin B Fused to Fimbria 2 Protein Protects against Bordetella pertussis Infection. BioMed Research International. Volume 2014 (2014), Article ID 421486, 11 pages

Rumbo M and Hozbor D. Development of improved pertussis vaccines. Hum Vaccin Immunother. 2014 Jun 5;10(8). ISSN: 2164-5515 (Print), 2164-554X (Electronic)

Fallo A, Manonelles G, Hozbor D, Lara C, Huespe M, Mazzeo S, Canle O, Galas M, López E. Pertussis seroprevalence in adults, post-partum women and umbilical cord blood. Arch Argent Pediatr. 2014 Aug;112(4):315-322. ISSN 0325-0075 versión impresa ISSN 1668-3501 versión on-line

Viviana Romanin, Vanina Agustinho, Califano, Sandra Sagradini, Analía Aquino, María del Valle Juárez, Julián Antman, Carlos Giovacchini, Marcelo Galas, Claudia Lara, Daniela Hozbor, Ángela Gentile y Carla Vizzotti. Situación epidemiológica de coqueluche y estrategias para su control. Argentina, 2002-2011. Arch Argent Pediatr. 2014 112(5):413-20. doi: 10.1590/S0325-00752014000500005. ISSN 0325-0075 versión impresa ISSN 1668-3501 versión on-line

Luiza Helena Falleiros Arlant, Agustín de Colsa, Dario Flores, José Brea, Maria L. Avila Aguero; and Daniela Hozbor. Pertussis in Latin America: Epidemiology and Control Strategies. Expert Rev Anti Infect Ther. 2014 Oct;12(10):1265-75. doi: 10.1586/14787210.2014.948846. ISSN: 1478-7210 (print), 1744-8336 (electronic)

Maximiliano Ormazábal, Erika Bartel, María Emilia Gaillard, Daniela Bottero, Agustina Errea, M. Eugenia Zurita, Griselda Moreno, Martin Rumbo, Celina Castuma, Dario Flores, María Julia Martín and Daniela Hozbor. Characterization of the key antigenic components of pertussis vaccine based on outer membrane vesicles. Vaccine. 2014 Oct 21;32(46):6084-90. doi: 10.1016/j.vaccine.2014.08.084. ISSN: 0264-410X

Errea A, González Maciel D, Hiriart Y, Hozbor D, Rumbo M. Intranasal administration of TLR agonists induces a discriminated local innate response along murine respiratory tract. Immunol Lett. 2015 Jan 28. pii: S0165-2478(15)00005-X. doi: 10.1016/j.imlet.2015.01.004. ISSN: 0165-2478

Tan T, Dalby T, Forsyth K, Halperin SA, Heininger U, Hozbor D, Plotkin S, Ulloa-Gutierrez R, von König CH. Pertussis Across the Globe: Recent Epidemiologic Trends From 2000-2013. Pediatr Infect Dis J. 2015 Sep;34(9):e222-32. doi: 10.1097/INF.0000000000000795. Review. ISSN: 0891-3668. Online ISSN:1532-0987.

P. Pesco, P.Bergero, G. Fabricius and D. Hozbor. Mathematical modeling of delayed pertussis vaccination in infants. Vaccine 2015 33(41):5475-80.. doi: 10.1016/j.vaccine.2015.07.005 ISSN: 0264-410X

Gaillard, María; Bottero, Daniela; Moreno, Griselda; Rumbo, Martin; Hozbor, Daniela. Strategies and new developments to control pertussis, an actual health problem. Pathogens and Disease 2015 aceptado para su publicación. Online ISSN: 2049-632X

M. Fingermann, D. Hozbor. Acid tolerance response of Bordetella bronchiseptica in avirulent phase. Microbiological Research 181 (2015) 52–60. ISSN: 0944-5013

Bottero, D., Gaillard ME., Zurita E., Moreno G., Sabater Martinez, D., Bartel., Bravo S., Carriquiriborde F., Errea A., Castuma C., Rumbo M. and Hozbor D. Characterization of the immune response induced by pertussis OMVs-based vaccine. Vaccine. 14;34(28):3303-9. doi: 10.1016/j.vaccine.2016.04.079.

Henri Bailon Calderon, Nancy León Janampa, Carlos Padilla Rojas, Daniela Hozbor. Increase in pertussis cases along with high prevalence of two emerging genotypes of bordetella pertussis in perú, 2012. BMC Infectious Diseases 2016 Aug 17;16(1):422

Carbonetti NH, Wirsing von König CH, Lan R, Jacob-Dubuisson F, Cotter PA, Deora R, Merkel TJ, van Els CA, Locht C, Hozbor D, Rodriguez ME. Highlights of the 11th International Bordetella Symposium: from Basic Biology to Vaccine Development. Clin Vaccine Immunol. 2016 Nov 4;23(11):842-850. Review.

Fallo AA, Neyro SE, Manonelles GV, Lara C, Hozbor D, Zintgraff J, Mazzeo S, Davison HE, González S, Zapulla E, Canle O, Huespe M, Galas M, López EL. Prevalence of Pertussis Antibodies in Maternal Blood, Cord Serum, and Infants From Mothers With and Those Without Tdap Booster Vaccination During Pregnancy in Argentina. J Pediatric Infect Dis Soc. 2016 Dec 30. pii: piw069. doi: 10.1093/jpids/piw069.

Sisti F, Fernández J, Cordero A, Casabuono A, Couto A, Hozbor D. Modifications of Bordetella bronchiseptica core lipopolysaccharide influence immune response without affecting protective activity. Bioorg Med Chem Lett. 2016 Dec 21. pii: S0960-894X(16)31329-4. doi: 10.1016/j.bmcl.2016.12.049.

Hozbor DF. Outer membrane vesicles: an attractive candidate for pertussis vaccines. Expert Rev Vaccines. 2016 Dec 30:1-4. doi: 10.1080/14760584.2017.1276832.

CAPITULOS DE LIBROS

Capítulo 4 Molecular population genetic analysis of emerged bacterial pathogens. M.E.Gaillard, D. Bottero, J. Fernández, F. Sisti, C.E, Castuma, and D. Hozbor. Título del Libro: Bacterial Populations: Basic and Applied Aspects of Their Structure and Evolution RESEARCH SIGNPOST TRANSWORLD RESEARCH NETWORK. Editor Lodeiro Anibal. 2009 ISBN: 8130802716. ISBN-13: 9788130802718.

Capítulo VI: Efectos del pH y la Temperatura. A. Lodeiro-D. Hozbor. Catálisis Enzimática. Fundamentos Químicos de la Vida. EDULP. La Plata (en prensa y ISBN en trámite). 2015

Capítulo IX: Purificación de Enzimas. D. Hozbor-D. Bottero. . Catálisis Enzimática. Fundamentos Químicos de la Vida. EDULP. La Plata (en prensa y ISBN en trámite). 2015

Capítulo X: Protocolos de Ensayo de Actividad Enzimática D. Hozbor-D. Bottero. . Catálisis Enzimática. Fundamentos Químicos de la Vida. EDULP. La Plata (en prensa y ISBN en trámite). 2015

TECNOLÓGICOS / TÉCNICOS

Tutorial para notificación de Coqueluche a través de SIVILA. Sep 2010

Actualización de Recomendaciones para las Infecciones Respiratorias Agudas. Ministerio de Salud de la Nación. Junio 2012.

Recomendaciones ante situación de Brote de Coqueluche (http://www.vacunas-vacsal.org.ar/documentos/Informes%20mensuales/Coqueluche%20en%20
Brote%20-%20MSAL%20Agosto%202012.pdf)

DE DIVULGACIÓN

Episteme. Revista de Ciencias. Instituto de Física La Plata CONICET. Año 4 N°11. Pag. 18-20. 2011. Pertussis, una enfermedad inmunoprevenible vigente. Dra. Daniela Hozbor

Vigilancia nacional de tos convulsa, coqueluche o pertussis: Experiencia del Hospital Garrahan y de los Laboratorios Nacionales de Referencia. D. Hozbor, D. Flores, D. Bottero, C. Lara, S. Fiori, C. Sorhouet, M. Regueira, M. Galas, M.E. Venuta, H. Lopardo. Revista Medicina Infantil. Número 4- 2010;Volumen XVII, 366